A Reliable Supply of Deuterium Oxide for the Pharmaceutical Industry

We deliver a long-term and scalable supply of deuterium oxide for biomedical research.

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Close up shot of a deutraMed™ Deuterium Oxide D₂O Deuterium Gas bottle

An easy solution for complex problems

Deuterium oxide is the new method of choice for analyzing protein synthesis for prolonged periods of time. D2O is easy to administer which means there are a variety of uses. Here are just a few ways D2O is transforming pharmaceutical research:

  • Analysis of protein synthesis in humans and other species over prolonged periods of time. 1,2
  • Body composition analysis and body condition indexes for obesity and fitness research3 including childhood obesity4,5.
  • Sleep deprivation and high intensity interval training studies6.
  • Determining the amount of human milk consumed by an infant, and the exclusivity of breastfeeding practices7,8.
Pharmacist supplying medicine with deuterium

Deuterium for Therapeutic Drugs

Deuterium can be substituted for protium in the manufacture of certain drugs without materially altering the drug’s therapeutic benefits. These deuterated drugs slow the metabolism of the drug while maintaining full potency and effectiveness. This can lead to longer benefits, fewer and smaller doses, as well as fewer side-effects.

Deuterium slows the rate of metabolism by forming a stronger chemical bond than protium does. This allows deuterium to be used as intermediates for many pharmaceuticals.

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References

[1]

Beylot, M. Use of stable isotopes to evaluate the functional effects of nutrients. Current Opinion in Clinical Nutrition and Metabolic Care (2006). doi:10.1097/01.mco.0000247480.17829.34

[2]

Emson, C. L. et al. A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis. Clin. Transl. Med. (2013). doi:10.1186/2001-1326-2-12

[3]

V., O. Body composition as a tool to monitor overweight and obesity: The role of nuclear techniques. Obes. Facts (2018). doi:http://dx.doi.org/10.1159/000489691

[4]

Reilly, J. J., Kelly, J. & Wilson, D. C. Accuracy of simple clinical and epidemiological definitions of childhood obesity: Systematic review and evidence appraisal. Obesity Reviews (2010). doi:10.1111/j.1467-789X.2009.00709.x

[5]

Adom, T., Kengne, A. P., Villiers, A. De, Boatin, R. & Puoane, T. Diagnostic accuracy of body mass index in defining childhood obesity: Analysis of cross-sectional data from ghanaian children. Int. J. Environ. Res. Public Health (2020). doi:10.3390/ijerph17010036

[6]

Saner, N. J. et al. The effect of sleep restriction, with or without high-intensity interval exercise, on myofibrillar protein synthesis in healthy young men. J. Physiol. (2020). doi:10.1113/JP278828

[7]

Slater, C., Kaestel, P. & Houghton, L. Assessing Breastfeeding Practices Objectively Using Stable Isotope Techniques. Annals of Nutrition and Metabolism (2019). doi:10.1159/000503667

[8]

Moore, S. E. et al. Use of stable-isotope techniques to validate infant feeding practices reported by Bangladeshi women receiving breastfeeding counseling. Am. J. Clin. Nutr. (2007). doi:10.1093/ajcn/85.4.1075